North Korea, the war in Syria and trade are all expected to be discussed during US Vice President Mike Pence's whirlwind weekend visit to Australia.

America's second most powerful man after US President Donald Trump is due to meet Prime Minister Malcolm Turnbull, senior government officials and business leaders in Sydney on Saturday.

Amid tight security, Mr Pence touched down on Friday night for the final leg of his Asia-Pacific tour before departing for Hawaii on Monday.

Vice President of the United States Mike Pence and his family, wife Karen Pence and daughter Charlotte Pence arrive at Sydney International Airport. (AAP)

Vice President of the United States Mike Pence and his family, wife Karen Pence and daughter Charlotte Pence arrive at Sydney International Airport. (AAP)

NSW Treasurer Dominic Perrottet, Australian ambassador to the US Joe Hockey, acting US ambassador to Australia James Carouso and consul-general Valerie Fowler were also there to meet the vice president.

Sydneysiders will witness "substantial" motorcades and rolling road closures during Mr Pence's whirlwind visit to the city this weekend, which has prompted a major security operation.

Observers believe Mr Pence will use his time in Sydney to smooth relations between Washington and Canberra following Mr Trump's outburst at Australia's planned asylum-seeker deal during his notorious phone call with Mr Turnbull in January.

Mr Pence's visit is part of a 10-day tour of the Asia Pacific, during which he has visited South Korea, Japan and Indonesia.

During his first official tour to the region, Mr Pence has been keen to emphasise the commitment by the US to its alliances and partnerships in the region.

Mike Pence speaks to Japanese and US servicemen aboard the USS Ronald Reagan in Japan. (AAP)

Mike Pence speaks to Japanese and US servicemen aboard the USS Ronald Reagan in Japan. (AAP)

Mike Pence speaks at an event in Japan. (AAP)

Mike Pence speaks at an event in Japan. (AAP)

"The truth is President Trump's election has created a need to reassure allies about Mr Trump's intentions," Lowy Institute executive director Michael Fullilove said.

"Mr Pence is a traditional conservative Republican who has an alliance-centric view of the world and I think the purpose of his mission is to telegraph continuity to Japan and Korea, Australia and Indonesia.

"The reason to do that is we have a president who for three decades has held to a very different world view, who has basically decried the global liberal order, who's shown himself to be hostile to free trade, someone who is sceptical of alliances and suspicious of institutions like the United Nations."

Mr Pence will be accompanied by his wife Karen and their two daughters Audrey and Charlotte.

© AAP 2017

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